Free from any effect on anorectal motor function or impair rectal sensation in either healthy volunteers or patients with constipation.
Faster acting than other laxatives
Prucalopride has a rapid onset of enterokinetic activity and increases the number of complete spontaneous bowel movements. Adequate relief of constipation among patients with severe constipation occurs significantly more frequently in patients taking prucalopride compared with placebo.
[Georges Coremans : Core Evid. 2008 Jun; 3(1): 4554.]
Useful in drug-unbresponsive chronic constipation
Data from large randomized, controlled clinical trials indicate that it is effective in CC and offers a new therapeutic alternative for those whose condition fails to respond to conventional laxatives.
[Eamonn M. M. Quigley : Therap Adv Gastroenterol. 2012 Jan; 5(1): 2330.]
Indications :
- Chronic constipation
- Constipation due to spinal cord injury
- Constipation secondary to chronic daily opioid use
Dosage :
As per Guidelines of Doctor.
Or
A 2 mg dose regimen appears optimal to start, with dose escalation when needed and dose reduction in the case of adverse events consistent with the prokinetic action that would preclude further treatment with 2 mg once daily.