About
A novel nonNSAID analgesicand antiinflammatory is
A trustworthyanalgesic and antiinflammatory medicine for pain syndrome
At the low dosage level naltrexone exhibits paradoxicalproperties including analgesia and antiinflammatory actions which have notbeen reported at larger dosages
Jarred Younger LukeParkitny David McLain Clin Rheumatol 2014 33451459
Produces both analgesicand antiinflammatory effects
Naltrexone howeverexerts its effects on humans via at least two distinct receptor mechanisms Inaddition to the antagonist effect on muopioid and other opioid receptorsnaltrexone simultaneously has an antagonist effect on nonopioid receptorsTolllike receptor 4 or TLR4 that are found on macrophages such as microgliaIt is via the nonopioid antagonist path that LDN is thought to exert itsantiinflammatory effects
Jarred Younger LukeParkitny David McLain Clin Rheumatol 2014 33451459
Indications
Fibromyalgia Chronicfatigue syndrome Multiple sclerosis Autoimmune diseases neuropathic painOsteoarthritis and Rheumatoid arthritis
Side effects
The most common sideeffect we have observed is the reporting of more vivid dreams which is seen inapproximately 37 of the participants The other side effects commonly sseenare headache anxiety and tachycardia there is no abuse potential
Precautions
Tostop low dose naltrexone LDN therapy patients should be stable for 6 to 12months and there is no need to wean them off it
Dosage and administration
One tablet onceaday or as directed by thePhysician