About
Reduce embarassment reduce struggle with
Ensures predictable response
Provides significant benefits inAlzheimers disease
Improves cognition function and global status of patients
Reduces rates of marked clinical worsening
Provides good safety and tolerability
These results support and extend previous evidence that combinationtreatment with memantine added to stable donepezil in patients withmoderate AD and in those with moderate to severe AD is associatedwith significant benefits in reducing 24week decline in cognitionfunction and global status Combination treatment produces substantiallyreduced rates of marked clinical worsening has good safety and tolerability and generates effectsizes that are both statistically significant and clinically meaningful
Atri A et al Alzheimers Res Ther 2013 Jan 21516
Better than donepezil montherapy
In patients with moderatetosevere AD combination treatment withthe Nmethyldaspartate receptor antagonist memantine and the ChEIdonepezil has produced significant benefits in cognition function
behavior global outcome and care dependency compared withdonepezil treatment alone
Gauthier S Molinuevo JL Alzheimers Dement 2013 May9332631
Reduces risk of nursing home admission
Indicated in
Moderate to severe AD
Other dementia