UNDECANOATE-40 MG.

Product Description

Male hypogonadism MH is a clinical and biochemical syndrome caused by inadequate synthesis of testosterone Untreated MH can result in longterm effects including metabolic musculoskeletal moodrelated and reproductive dysfunction Among Indian men above 40 years of age the prevalence of MH is 2029 Among men with type 2 diabetes mellitus 207 are found to have hypogonadism However due to suboptimal patientphysician communication MH remains heavily underdiagnosed

Sanjay Kalra et al Int J Endocrinol 2023 Feb 222023

A depressed male youth

The ester prodrug of testosterone for the treatment of male hypogonadism

 Effectively restores the levels of testosterone thereby improving symptoms and signs of  testosterone deficiency

Male patients with hypogonadism receiving oral testosterone undecanoate 225 mg twice daily demonstrated Improvements in libido and sexual frequency Serum testosterone concentrations were within the reference range in 87 of patients without dose titration

Martin Miner et al Andrology  2024 Sep 10 

Reduces chances of metabolic syndrome

Testosterone deficiency in men is implicated as a risk factor for metabolic syndrome and Type 2 diabetes and is independently associated with components of the metabolic syndrome  visceral obesity insulin resistance hyperglycemia hypertension and dyslipidemia 

James S Bernstein and Om P Dhingra Ther Adv Urol 2024 Vol 16 117

Better than other exogenous testosterone compounds

TU has increased compliance due to the option of oral intake and a pharmacokinetic profile that allows for far less frequent dosing compared to other exogenous testosterone compounds 

Katherine Campbell et al Drug Healthc Patient Saf 2023 15 7384

Improves quality of life of patients with testosterone deficiency

It is concluded that androgen supplement therapy with oral testosterone undecanoate Andriol restores the quality of life through improvement of general body functions in men with testosterone deficiency 

Park et al The Aging Male 200368693

Indications 

Primary hypogonadism and hypogonadotropic hypogonadism such as Congenital or acquired primary hypogonadism and Congenital or acquired hypogonadotropic hypogonadism covering idiopathic oligozoospermia asthenozoospermia or teratozoospermia

Side effects 

Fluid retention nervousness mood disturbance myalgia hypertension pruritus priapism prostatic cancer prostatic disorder abnormal hepatic function  lipid abnormality increased PSA inhibition of testicular function testicular atrophy and oligospermia impotence gynecomastia epididymitis and bladder irritability nausea cholestatic jaundice peliosis hepatis polycythemia headache anxiety depression generalized paresthesia and rarely anaphylactoid reaction

Dosage 

120 mgday in divided doses or as directed by the Physician