Increases sperm count in oligospermic patients
- Enhances Leydig cell secretory function (LCSF)
- Raises serum levels of insulin-like-3 peptide (INSL3)
- Increases sperm concentration and sperm motility
We suggest that PDE5-i enhances LCSF, as the mean INSL3 concentration was significantly greater after PDE5-i administration than before, within groups A and B. This enhancement in LCSF might contribute to the increase in sperm concentration and sperm motility after administration of PDE5-i.
[Dimitriadis F et al; BJU Int. 2010 Feb 22.]
Indicated in ED caused by difficult-to-treat
etiologies such as
- radical prostatectomy
- severe diabetes
- spinal cord injury
- minor depression
- multiple sclerosis
- drug-induced ED