DONEPEZIL-5 MG. & MEMANTINE-5 MG.

About DONEPEZIL-5 MG. & MEMANTINE-5 MG.

Reduce embarassment, reduce struggle with...

Ensures predictable response.

Provides significant benefits inAlzheimerïs disease

- Improves cognition, function and global status of patients

- Reduces rates of marked clinical worsening

- Provides good safety and tolerability

"These results support and extend previous evidence that combinationtreatment with memantine added to stable donepezil in patients withmoderate AD, and in those with moderate to severe AD, is associatedwith significant benefits in reducing 24-week decline in cognition,function and global status. Combination treatment produces substantiallyreduced rates of marked clinical worsening, has good safety and tolerability, and generates effectsizes that are both statistically significant and clinically meaningful.ï

[Atri A et al; Alzheimers Res Ther. 2013 Jan 21;5(1):6]

* Better than donepezil montherapy

"In patients with moderate-to-severe AD, combination treatment withthe N-methyl-d-aspartate receptor antagonist memantine and the ChEIdonepezil has produced significant benefits in cognition, function,

behavior, global outcome, and care dependency, compared withdonepezil treatment alone.ï

[Gauthier S, Molinuevo JL. Alzheimers Dement. 2013 May;9(3):326-31]

* Reduces risk of nursing home admission

* Indicated in :

- Moderate to severe AD

- Other dementia