BUPRNORPHIN AND NALOXONE TABLETS

Product Description

Exerts its analgesic effect by binding to the mu-opioid receptors in the CNS. It has a longer duration of analgesic action than morphine. Its partial agonist activity gives it a low level of physical dependence. Buprenorphine and morphine show similar dose-related resp depressant effect.

Mixed opiate agonist-antagonist (buprenorphine) combined with naloxone (an opiate antagonist); naloxone is included as an abuse deterrent Used for induction treatment in patients dependent on heroin or other short-acting opioids who are in opioid withdrawal; also used for maintenance treatment of opioid dependence and narcotic painkillers.

Also approved for use in adults to treat opioid dependence, which is now called OUD. (With OUD, opioids are chronically misused, which means theyïre taken in a way other than how theyïre prescribed to be used. With chronic misuse, misuse happens over and over.) With dependence, your body needs a drug in order for you to feel normal. Buprenorphine tablets are part of a complete treatment program for OUD that usually includes counseling or psychotherapy.

Naloxone has an extremely high affinity for -opioid receptors in the central nervous system. A -opioid receptor competitive antagonist, and its rapid blockade of those receptors often produces rapid onset of withdrawal symptoms. Also has an antagonist action, though with a lower affinity, at ï- and δ-opioid receptors. Pharmacokinetics Naloxone is a pure opioid antagonist that acts competitively at opioid receptors. 

Indications :
Abuse deterrent
Opioid dependence/addiction & narcotic painkillers
Opioid withdrawal