Acts as both calcium antagonist and anti-glutamate agent
Effective prophylactic treatments reducing high glutamate plasma levels found in migraine patients could act on the underlying mechanism that contributes to cause migraine.
[Ferrari A et al; Cephalalgia. 2009 Apr;29(4):423-9]
Also valuable in paediatric headache prevention
Indicated in :
- Migraine prophylaxis
- Essential tremor
- As add-on treatment, in some patients with partial or generalized epilepsy
- Vertigo of either peripheral or central origin
- Cerebrovascular insufficiency
Starting /maintenance dose :
Two 5 mg tablets (10 mg) at night in patients less than 65 years of age 5 mg daily in patients older than 65 years
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